A historical threshold in organ transplantation
The most common causes of chronic kidney disease type 2 diabetes ve high blood pressure found 62 year old Richard (Rick) Slayman‘s condition after surgery is good ve soon discharged It was stated that it was expected to be. The surgery also marks the end of xenotransplantation (the use of animal organs in humans), which scientists have been researching for decades due to a shortage of suitable human donor organs. Kidney is the organ most needed for organ transplantation globally.
Even though this transplant has been carried out, there are still obstacles before the transplantation of pig organs into the human body. There is a big obstacle. Joren Madsen, Director of the Massachusetts General Hospital Organ Transplant Center, made the following statements in his statement: “If it was easy we would have done it by now but it is not. “The human immune system reacts incredibly violently to the pig organ.”
The solution may be CRISPR
Along with pig kidneys, scientists are also exploring using gene-edited pig hearts in humans. Although pig hearts have been transplanted into two humans so far, in both cases the patients only survived for a few months.
However, Slayman Kidney transplant was performed at the hospital in 2018However, he had to undergo dialysis again last year due to signs of failure. However, dialysis caused complications; The patient’s blood vessels were clotting and failing. At this point, Slayman’s doctors recommended a pig kidney transplant. Under normal circumstances, it is not possible to accept this type of suggestion, but US Food and Drug Administration (FDA) “Experimental treatment should not be used in these special, life-threatening situations and when there is no other option.”compassionate use“He can allow it.
As a result of the transplant, Slayman’s condition is good and his kidney is working. Long-term results are not yet clear not. Scientists say it is difficult to make predictions, too much unknown that there is a factor and that done for the first time conveys. The surgery and procedure will be deemed successful if Slayman does not need to undergo dialysis again. The team hopes the pig kidney will improve Slayman’s health and buy him time to receive another donated human kidney. In previous preclinical tests conducted by eGenesis, the kidney for more than two years It appeared to be operating normally.
Source
https://www.washingtonpost.com/health/2024/03/21/gene-edited-pig-kidney-transplant/
https://apnews.com/article/pig-kidney-transplant-boston-c7fb54b1b1f1ece3b41b85f105fe4b98
https://hms.harvard.edu/news/first-genetically-edited-pig-kidney-transplanted-human
This news our mobile application Download using
You can read it whenever you want (even offline):
Source link: https://www.donanimhaber.com/genetigi-degistirilmis-domuz-bobregi-ilk-kez-insana-nakledildi–175613