New treatment methods have been opened!

Migraine is a health problem, even an illness, that negatively affects the lives of many people and manifests itself with severe headaches and various symptoms. Scientists from the University of Rochester have taken an important step in the treatment of this disease by solving the mechanism behind this disease. The discovery may enable the development of new and effective methods of treating the condition.

How was the mystery of migraine solved and what are the new treatment methods?

University of Rochester researchers discovered that migraine pain causes movements in the cerebrospinal fluid (CSF) around the brain. This movement causes the release of certain proteins, which interact with the nerves and cause pain. This new finding enabled the discovery of new proteins that can be targeted in the treatment of the disease.

Maiken Nedergaard, co-director of the Center for Translational Neuromedicine at the University of Rochester, who led the study. “In this study, we describe the interaction between the central and peripheral nervous system of increased concentrations of proteins released in the brain during migraine-associated spreading depolarization,” said. This discovery opens many new doors to strengthen existing treatments and identify new targets.

Migraine attacks occur after cortical spreading depression caused by the spread of glutamate and potassium. This process spreads in a wave that affects the brain’s oxygen levels and blood flow. During a migraine attack, the brain cannot feel pain, but a communication process begins between the brain and peripheral sensory nerves.

The researchers showed that CSF carries these proteins to a large bundle of nerves called the trigeminal ganglion, which collects sensory information from the head and face area. This new finding takes an important step in explaining the cause of post-attack pain.

Nedergaard and his team identified 12 ligand proteins that are released during an attack and bind to nerve receptors. One of these proteins, the calcitonin gene-related peptide (CGRP) protein, is the target of new drugs currently used to prevent and treat migraine.

As a result, this new research has solved the mystery behind migraine, paving the way for new treatment methods. For many people struggling with migraine, this development points to a promising future. Scientists believe these discoveries could revolutionize migraine treatment.

If you wish, you can download the original published article of the research. from here you can read. What are you thinking? Please don’t forget to share your thoughts with us in the comments section below.