A critical advance in understanding the human brain
Animal studies remain limited due to differences in brain structure and function between species. On the other hand, laboratory-grown brain cells pose another challenge as they tend to lack the characteristic connections of cells in the human brain. Previous studies attempted to create brain circuits under laboratory conditions, and although progress was made in this field, the lack of characteristics limited the research.
Now, researchers from the University of Tokyo have developed an experimental tissue in which human stem cells are grown into brain-mimicking structures.neural organoidsThese special tissues are created in experiments where human stem cells are grown into 3D structures to mimic brain development. Elip made the organoids by connecting axonal bundles that resemble bridges connecting different areas in a living human brain.
Plasticity is so important because it helps researchers understand how brain-like structures respond and adapt to changes. This means learning more about how artificial brain tissues work.
senior author of the study Yoshiho Ikeuchi“These findings suggest that axonal bundle connections are important for developing complex networks. In particular, complex brain networks are responsible for many deep functions such as language, attention, and emotion.” says.
Considering that changes in brain networks have been associated with various neurological and psychiatric conditions, a better understanding of brain networks is important. Understanding the dynamics of laboratory-grown tissues may enable the discovery of how these networks form and change over time in different situations. This makes scientists to better treatments can take away.
Source
https://www.sciencedaily.com/releases/2024/04/240410112224.htm
https://www.sci.news/othersciences/neuroscience/human-brain-mimicking-tissues-12848.html
https://www.nature.com/articles/s41467-024-46787-7
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